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On this case, more effort and specific quests need to be accomplished to be able to unlock every talent. P M Haney, J W Slot, R C Piper, D E James, M Mueckler; Intracellular concentrating on of the insulin-regulatable glucose transporter (GLUT4) is isoform particular and impartial of cell type.. RC Piper, C Tai, JW Slot, CS Hahn, CM Rice, H Huang, DE James; The efficient intracellular sequestration of the insulin-regulatable glucose transporter (GLUT-4) is conferred by the NH2 terminus. It's concluded that the NH2 terminus of GLUT-4 incorporates a phenylalanine-based targeting motif that mediates intracellular sequestration at least partly by facilitating interaction of the transporter with endocytic equipment positioned on the cell floor. The H2O2 reduction and the selection of protein A to stabilize the gold for uptake experiments lowered the stickiness of the endocytosis marker to the floor of the living cells, thus offering an uncompromised fluid-section marker. Mutations at different amino acids surrounding Phe5 also precipitated elevated cell floor expression of GLUT-four however not to the same extent because the Phe5 mutation.